Targeting NCAPD2 as a Therapeutic Strategy for Crohn’s Disease: Implications for Autophagy and Inflammation
Our results show that NCAPD2 suppresses autophagy and worsens intestinal inflammation by modulating mTOR signaling and impacting the NF-κB pathway, suggesting a critical role in CD progression. Targeting NCAPD2 could be a promising therapeutic approach to stop CD advancement.
Authors
- Haoran Zhao (ORCID: https://orcid.org/0000-0002-0859-4136)
- Bolin Yang (ORCID: https://orcid.org/0000-0002-2474-4085)
- Can Wang (ORCID: https://orcid.org/0000-0002-6905-8126)
- Yuxia Gong
- Hao Chen (ORCID: https://orcid.org/0000-0001-8937-4946)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-5388-9574)
- Ping Liu (ORCID: https://orcid.org/0000-0002-6255-184X)
- Hao Ge (ORCID: https://orcid.org/0009-0000-3960-3245)
- Lichao Qiao
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Normal University (CN)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1093/ibd/izae211
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions