hUC-MSCs mitigate atherosclerosis induced by a high-fat diet in ApoE−/− mice by regulating the intestinal microbiota
HFD led to dysregulation of intestinal flora homeostasis and induced aberrant expression levels of NLRP3, resulting in a decrease in the Young's modulus of plaques. However, hUC-MSCs treatment improved the biomechanical properties of plaque by modulating the intestinal flora and NLRP3, thereby elevating plaque stability and minimizing the risk of plaque rupture.
Authors
- Yuanhe Wang (ORCID: https://orcid.org/0000-0002-0012-1756)
- Bing Xia (ORCID: https://orcid.org/0000-0002-1637-7908)
- Xiaorong Yang (ORCID: https://orcid.org/0000-0001-9463-8811)
- Youbin Liu (ORCID: https://orcid.org/0000-0002-7086-255X)
- Jialin Dai (ORCID: https://orcid.org/0000-0002-9471-9475)
- Wenxin Wu (ORCID: https://orcid.org/0009-0005-7504-8273)
- Jiawen Wang (ORCID: https://orcid.org/0000-0002-9382-9496)
- Jianwei Xu (ORCID: https://orcid.org/0000-0002-3243-4220)
- Lin Yang (ORCID: https://orcid.org/0000-0003-2212-7478)
- Jun Wu (ORCID: https://orcid.org/0000-0002-6785-6976)
- Cuiyun Le
- Tianbao Qian
Institutions
- Guiyang Medical University (CN)
- Ganzhou People's Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Gannan Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38698
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.94