Invastigate The Serum Level of Interleukin-4 In Patients with Chronic Rhinosinositis with Nasal Polyps and Healthy Individuals

Objective: Interleukin-4 plays several biological roles, including stimulating the proliferation of activated B and T cells and differentiating B cells into plasma cells. This study aimed to determine whether the etiology of chronic rhinosinusitis with nasal polyps (CRSwNPs) is associated with serum levels of interleukin-4. Patients and Methods: a blood samples from 35 Iraqi patients—21 men and 14 women—who had nasal polyps as well as a control group of 35 healthy volunteers were collected. The serum was then separated in a plain tube, and an enzyme-linked immunosorbent assay method was used to determine the optical density of Interleukin-4 in the serum (ELISA) Results: Serum levels of interleukin-4 were significantly higher in the patient group compared to the control group (P < 0.001). There was no significant correlation between serum interleukin-4 levels and age or gender in either group. Conclusions: Individuals who have NPs had elevated degrees of IL-4