Oxygen-Dependent Aspects of the Action of Asprosyn

A new hormone from the group of adipokines, called asprosin, was discovered in adipose tissue, which is a regulator of the body’s reactions to short-term fasting, initiates the release of glucose from the liver and increases appetite, and increases the total amount of energy reserves in adipose tissue. This hormone, determining the bioenergetic status of the body, affects the oxygen content in tissues, and, accordingly, the oxygen transport function of the blood in case of excess body weight and insulin resistance. In persons with an increased content of asprosin with overweight and obesity of the first degree, as well as with insulin resistance, a change in the position of the oxyhemoglobin dissociation curve is observed, accompanied by an increase in the concentration of the gas transmitter nitrogen monoxide and a decrease in the level of hydrogen sulfide. This factor is involved in the regulation of the gas transmitter system and the formation of blood oxygen transport mechanisms. The contribution of asprosin to the formation of oxygen supply and adaptive reserves of the body in individuals with metabolic disorders, which reflects a new aspect of the mechanism of its action.