Single-cell transcriptomics reveals e-cigarette vapor-induced airway epithelial remodeling and injury
This study reveals distinct characteristics in e-cigarette vapor-induced airway epithelial remodeling, pointing to Notch signaling pathway as a potential targeted intervention for e-cigarette vapor-caused ciliated cell differentiation defects and cilia injury. In addition, a decrease in SCGB1A1 proteins is associated with e- cigarette users, indicating a potential lung injury marker for e-cigarette users.
Authors
- Weitao Cao (ORCID: https://orcid.org/0000-0002-1113-603X)
- Yumin Zhou (ORCID: https://orcid.org/0000-0002-0555-8391)
- Wenguang Yin (ORCID: https://orcid.org/0000-0003-1722-8637)
- Weifeng Zou (ORCID: https://orcid.org/0000-0002-6514-0704)
- Xingtao Jiang
- Guoping Hu (ORCID: https://orcid.org/0000-0003-0750-3375)
- Zehang Zhao
- Li Che
- Ruixue Yang
- Zehong Wu (ORCID: https://orcid.org/0000-0002-0977-4112)
- Pixin Ran
- Jia Li (ORCID: https://orcid.org/0000-0002-1452-8995)
- Tiejun Zhang
Institutions
- Guangzhou Experimental Station (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Shenzhen Sixth People's Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University Cancer Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Chest Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s12931-024-02962-4
- Citations
- 4
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- State Key Laboratory of Respiratory Disease
- National Natural Science Foundation of China
- Fudan University
- State Key Laboratory of Genetic Engineering
- Guangzhou Municipal Science and Technology Bureau
- Basic and Applied Basic Research Foundation of Guangdong Province