Localized delivery of therapeutics impact laryngeal mechanics, local inflammatory response, and respiratory microbiome following upper airway intubation injury in swine
The injured and intubated airway resulted in increased laryngeal stiffness. Local inflammation and the type of therapeutic administered impacted the bacterial composition within the upper respiratory microbiome, which in turn mediated local tissue healing and recovery.
Authors
- Gabriela Gonzales (ORCID: https://orcid.org/0000-0003-3958-0914)
- Teja Guda (ORCID: https://orcid.org/0000-0002-3218-2916)
- Ronit Malka (ORCID: https://orcid.org/0000-0002-9864-2698)
- Gregory R. Dion (ORCID: https://orcid.org/0000-0003-4389-3104)
- Lisa M. Marinelli (ORCID: https://orcid.org/0000-0001-8649-5259)
- Solaleh Miar (ORCID: https://orcid.org/0000-0001-8613-8091)
- Christine Lee (ORCID: https://orcid.org/0000-0001-9233-8962)
- Stacy Cook
Institutions
- Brooke Army Medical Center (US)
- University of Hartford (US)
- United States Army Institute of Surgical Research (US)
- The University of Texas at San Antonio (US)
- University of Cincinnati (US)
- Joint Base San Antonio (US)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s12931-024-02973-1
- Citations
- 1
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- University of Texas at San Antonio
- Directorate for Engineering
- Defense Health Agency