Targeting West Nile virus replicases: NS3 and heterodimers inhibitors
Tri and tetra-peptide inhibitors NS2B-NS3 ALLOSTERIC SITE INHIBITORSWe designed different tripeptides that mimic the structure of an already known reversible allosteric inhibitor (SID:852843) of the formation of the functional conformation of the NS3 protease of WNV and we studied these possible allosteric inhibitors by docking. Active tripeptide allosteric inhibitorPhe-Pro-Tyr-OH IC 50 = 48.30 11.07 M
Authors
- Cristina Peggion (ORCID: https://orcid.org/0000-0001-9716-800X)
- Riccardo Rigo (ORCID: https://orcid.org/0000-0002-6394-1583)
- Daniele Volpin
- Matia Sturlese
Publication Details
- Published
- 2024-09-20
- DOI
- https://doi.org/10.17952/37eps.2024.yif13
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00