Assessing the Sympatholytic Effects of SGLT2 Inhibitors in Anuric Haemodialysis Patients Using Microneurography: Study Protocol for a Mechanistic Proof-of-Concept Trial
This will be the first study evaluating the effects of SGLT2i on the SNS in haemodialysis subjects. This study aims to enhance our understanding of the potential role of SGLT2i-induced SNS reduction in the setting of markedly reduced renal function. The study has received ethics approval from the Royal Perth Hospital Human Research Ethics Committee (RGS0000003840) (Australian New Zealand Clinical Trials Registry [ANZCTR] ID: ACTRN12623001237673).
Authors
- Sayeh Heidari Nejad
- Srivathsan Thiruvengadam (ORCID: https://orcid.org/0000-0002-2678-6190)
- Mark R. Thomas (ORCID: https://orcid.org/0000-0001-7048-7764)
- Markus Peter Schlaich (ORCID: https://orcid.org/0000-0002-1765-0195)
- Awf Abdulrahman Shaban (ORCID: https://orcid.org/0000-0001-8973-4630)
- Sally Burrows (ORCID: https://orcid.org/0000-0002-8499-4537)
- Aaron Yee Shuen See (ORCID: https://orcid.org/0009-0008-5114-0106)
- Evgenija Blazeska
- Anu Joyson
- Antonella Soarez Dornelles
Institutions
- The University of Western Australia (AU)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1159/000541568
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00