Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer
For the first time, the research effectively discovered the objectives and mechanisms of nomilin in combating TNBC using network pharmacology, molecular docking, molecular dynamics simulation, proteome microarray and experimental confirmation, presenting a hopeful approach for treating TNBC.
Authors
- Haoyi Xiang
- Yangyang Guo (ORCID: https://orcid.org/0000-0002-4070-8703)
- Xiaowu Wang (ORCID: https://orcid.org/0000-0001-6753-227X)
- Liangchen Qu
- Rongrong Zhang (ORCID: https://orcid.org/0000-0002-1089-1869)
- Jingyao Zhou
- Zhixuan Wu (ORCID: https://orcid.org/0000-0003-0141-4785)
- Yanyi Xiao
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Ruian People's Hospital (CN)
- Wenzhou Central Hospital (CN)
- Taizhou Central Hospital (CN)
- Zhejiang Taizhou Hospital (CN)
- Zhejiang University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s10020-024-00928-2
- Citations
- 16
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 3.74