N6-Methyladenosine-mediated phase separation suppresses NOTCH1 expression and promotes mitochondrial fission in diabetic cardiac fibrosis
We identified a novel epitranscriptomic mechanism by which m<sup>6</sup>A-mediated phase separation suppresses Notch1 expression, thereby promoting mitochondrial fission in diabetic cardiac fibrosis. Our findings provide new insights for the development of novel treatment approaches for patients with diabetic cardiac fibrosis.
Authors
- Hui Tao (ORCID: https://orcid.org/0000-0003-3761-8659)
- Jingjing Yang (ORCID: https://orcid.org/0000-0001-8521-7492)
- He Sun
- Zhiyan Liu (ORCID: https://orcid.org/0000-0001-9668-7756)
- Mao Sui (ORCID: https://orcid.org/0000-0002-3772-6986)
- Kai Song
- Yang Zhou (ORCID: https://orcid.org/0000-0002-6967-421X)
- Bin Tu
- Rui Li (ORCID: https://orcid.org/0000-0001-7857-9735)
- Jian‐Yuan Zhao (ORCID: https://orcid.org/0000-0001-9861-0330)
- Li-Chan Lin
- Zhang Ye (ORCID: https://orcid.org/0000-0003-3495-5596)
- Zhenyu Liu (ORCID: https://orcid.org/0000-0001-5077-5777)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s12933-024-02444-3
- Citations
- 8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China