Decoding Diabetic Kidney Disease: In-Depth Analysis of Prevalence, Risk Factors, Biomarkers, and Management Strategies

End-stage kidney disease (ESKD) is primarily caused by diabetic kidney disease (DKD), a common ailment that affects people all over the world and results from diabetes mellitus. Hemodynamic, metabolic, and inflammatory factors interact to influence its development. However, these changes are not unique to DKD, necessitating the development of novel biomarkers to support diagnosis, tracking, evaluation of treatment efficacy, and outcome prediction. High blood sugar levels trigger the disease by increasing the production of reactive oxygen species. Despite its significance as a global medical condition, people often ignore it. DKD causes major challenges for the community, finances, and individuals. Symptoms often remain unnoticed until they become evident, resulting in significant consequences. The absence of detailed data and infrequent screening protocols impede the early identification of diabetic kidney disease (DKD). The right medications and a precise diagnosis could help regulate the illness, prolong life, and lessen the psychological and financial burden on those affected. DKD frequently emerges right after the condition becomes severe. This research aims to identify global cases, factors that heighten the risk of developing DKD, and potential indicators for early diagnosis of DKD. Keywords: Diabetes mellitus (DM), Diabetic kidney disease (DKD), Epidemiology, Prevalence, Biomarkers, Diagnosis, Management