Synergistic effects of calcium channel blockers and renin-angiotensin inhibitors with gemcitabine-based chemotherapy on the survival of patients with pancreatic cancer
Our results demonstrate a significant positive impact of ARBs, ACE inhibitors, and CCBs on survival in patients with pancreatic cancer treated with gemcitabine. The addition of these inexpensive and relatively safe drugs in patients with additional comorbidities may represent a potential therapeutic option in this indication. However, prospective clinical trials to evaluate the optimal patient population and further studies to determine the potential impact of these agents on chemotherapy are necessary.
Authors
- Łukasz Szymański (ORCID: https://orcid.org/0000-0003-0148-541X)
- Lucjan Wyrwicz (ORCID: https://orcid.org/0000-0003-0808-6892)
- Andrzej M. Śliwczyński (ORCID: https://orcid.org/0000-0002-0239-1637)
- Paulina Chmiel (ORCID: https://orcid.org/0000-0002-2608-5319)
- Leszek Kraj (ORCID: https://orcid.org/0000-0001-6509-5993)
- Tomasz Stokłosa (ORCID: https://orcid.org/0000-0001-6918-5056)
- Krzysztof Woźniak (ORCID: https://orcid.org/0000-0003-1791-0126)
- Maciej Słodkowski (ORCID: https://orcid.org/0000-0002-3881-5753)
Institutions
- Medical University of Warsaw (PL)
- Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences (PL)
- National Institute of Oncology (HU)
- Ministry of Interior and Administration (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1007/s00432-024-05962-5
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Ministerstwo Edukacji i Nauki