c-CBL/LCK/c-JUN/ETS1/CD28 axis restrains childhood asthma by suppressing Th2 differentiation
c-CBL alleviated asthma and suppressed Th2 differentiation by facilitating LCK ubiquitination, interrupting c-JUN activation and CD28 expression in vivo and in vitro. c-CBL/LCK/c-JUN/ETS1/CD28 axis was partially involved in childhood asthma, and may provide novel insights for clinical treatment for asthma.
Authors
- Tianyue Wang (ORCID: https://orcid.org/0009-0004-6003-7865)
- Nan Yang (ORCID: https://orcid.org/0009-0003-8139-4696)
Institutions
- China Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s10020-024-00872-1
- Citations
- 4
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- National Natural Science Foundation of China