Fontan haemodynamics in adults with obesity compared with overweight and normal body mass index: a retrospective invasive exercise study
Adults post-Fontan with obesity have worse aerobic capacity, increased Qs, higher filling pressures, and decreased arterial O2 saturation compared with those with overweight/normal BMI, both at rest and during exercise, mirroring the findings observed in the obesity phenotype of heart failure with preserved ejection fraction. Whether treating obesity and its cardiometabolic sequelae in Fontan patients will improve haemodynamics and outcomes requires further study.
Authors
- Rachael Cordina (ORCID: https://orcid.org/0000-0001-7882-389X)
- Kyla Lara-Breitinger (ORCID: https://orcid.org/0000-0001-9724-3065)
- C. Charles Jain (ORCID: https://orcid.org/0000-0002-1116-8541)
- Barry A. Borlaug (ORCID: https://orcid.org/0000-0001-9375-0596)
- Yogesh N.V. Reddy (ORCID: https://orcid.org/0000-0001-5322-0902)
- William R. Miranda (ORCID: https://orcid.org/0000-0001-8864-8474)
- Derek N. Opp
- A Egbe
- Heidi M Connolly
Institutions
- Mayo Clinic (US)
- Royal Prince Alfred Hospital (AU)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1093/eurjpc/zwae314
- Citations
- 6
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- U.S. Department of Defense
- National Heart, Lung, and Blood Institute