BTN3A1 expressed in cervical cancer cells promotes Vγ9Vδ2 T cells exhaustion through upregulating transcription factors NR4A2/3 downstream of TCR signaling
Through binding γδ TCRs, BTN3A1 expressed on tumor cells, which is induced by IFN-γ, can promote Vδ2 T cells to upregulate the expression of TFs NR4A2/3, thereby affecting their activation and expression of exhaustion-related molecules in the tumor microenvironment (TME). Therefore, targeting BTN3A1 might overcome the immunosuppressive effect of the TME on Vδ2 T cells in CC.
Authors
- Han Jiang (ORCID: https://orcid.org/0000-0002-2928-8496)
- Yafei Huang (ORCID: https://orcid.org/0000-0002-1711-2354)
- Xinyu Mei (ORCID: https://orcid.org/0000-0002-4204-2351)
- Liming Wang (ORCID: https://orcid.org/0000-0003-3354-2079)
- Zixuan Wang (ORCID: https://orcid.org/0000-0002-8264-1121)
- Jingyu Wang (ORCID: https://orcid.org/0000-0003-0218-8978)
- Huiling Chen (ORCID: https://orcid.org/0000-0002-7714-9693)
- Shan He (ORCID: https://orcid.org/0000-0002-8558-7490)
- Yifan Yang (ORCID: https://orcid.org/0000-0003-0947-5603)
- Xun Tian (ORCID: https://orcid.org/0000-0002-4602-7589)
- Min Wu (ORCID: https://orcid.org/0009-0002-7574-4648)
- Jian Liu (ORCID: https://orcid.org/0000-0002-6048-9333)
- Shen Qu
- Hangyu Liu
- Yuwei Zhang (ORCID: https://orcid.org/0009-0008-1016-7361)
- Hui Wang (ORCID: https://orcid.org/0009-0006-3512-9308)
Institutions
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s12964-024-01834-0
- Citations
- 9
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.54
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China