Maternal HIV infection and the milk microbiome
The milk microbiome varies by stage of lactation, by parity, and by region; however, we found no evidence that the human milk microbiome is altered by maternal HIV infection, disease severity, or antiretroviral therapy. Additionally, we found no association between the milk microbiome and transmission of HIV to the infant. Investigations including higher resolution microbiome approaches or into other potential mechanisms to understand why the approximately one million children born annually to women with HIV escape infection, but do not escape harm, are urgently needed. Video Abstract.
Authors
- Patricia M. Flynn (ORCID: https://orcid.org/0000-0003-4918-6881)
- Dhayendre Moodley (ORCID: https://orcid.org/0000-0003-1849-9631)
- Avy Violari (ORCID: https://orcid.org/0000-0002-9437-776X)
- Nicole H. Tobin (ORCID: https://orcid.org/0000-0001-6904-6128)
- Vanessa Rouzier (ORCID: https://orcid.org/0000-0002-9672-9474)
- Sean S. Brummel (ORCID: https://orcid.org/0000-0002-4116-404X)
- Louise Kuhn (ORCID: https://orcid.org/0000-0002-2305-8665)
- Grace M. Aldrovandi (ORCID: https://orcid.org/0000-0003-1604-9637)
- Fan Li (ORCID: https://orcid.org/0000-0002-2400-9021)
- Mary Glenn Fowler (ORCID: https://orcid.org/0000-0003-4484-9009)
- Sufia Dababhai
- Lameck Chinula
Institutions
- St. Jude Children's Research Hospital (US)
- Johns Hopkins University (US)
- University of Malawi (MW)
- University of California, Los Angeles (US)
- University of the Witwatersrand (ZA)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Cancer Research And Biostatistics (US)
- Gheskio Centers (HT)
- Perinatal HIV Research Unit (ZA)
- Sage Colleges (US)
Publication Details
- Journal
- Microbiome
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s40168-024-01843-8
- Citations
- 6
- Primary Topic
- Breastfeeding Practices and Influences
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- Children's Hospital of Philadelphia
- International Maternal Pediatric Adolescent AIDS Clinical Trials Network
- National Institutes of Health
- Center for AIDS Research, University of Washington
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development