Mass spectrometry imaging of two neocortical areas reveals the histological selectivity of schizophrenia-associated lipid alterations
Our study found a consistent yet differential association of schizophrenia with the brain lipidome composition of distinct neocortical areas, particularly subcortical white matter. These findings highlight the need for broader brain coverage in future schizophrenia research and underscore the potential of spatially resolved molecular analysis methods in identifying structure-specific effects.
Authors
- Аnna Morozova (ORCID: https://orcid.org/0000-0002-8681-5299)
- Pavel Mazin (ORCID: https://orcid.org/0000-0001-9268-3352)
- Marina Zavolskova (ORCID: https://orcid.org/0000-0003-4532-0721)
- Elena Stekolshchikova (ORCID: https://orcid.org/0000-0001-8607-9773)
- Philipp Khaitovich (ORCID: https://orcid.org/0000-0002-4305-0054)
- Maria Osetrova (ORCID: https://orcid.org/0000-0002-8174-9544)
- Yana Zorkina (ORCID: https://orcid.org/0000-0003-0247-2717)
- Denis Andreyuk (ORCID: https://orcid.org/0000-0002-3349-5391)
- Е. Н. Николаев (ORCID: https://orcid.org/0000-0001-6209-2068)
- Olga Efimova (ORCID: https://orcid.org/0000-0003-0842-3203)
- G. P. Kostyuk (ORCID: https://orcid.org/0000-0002-3073-6305)
- Gleb Vladimirov (ORCID: https://orcid.org/0000-0003-4623-4884)
Institutions
- Skolkovo Institute of Science and Technology (RU)
- Wellcome Sanger Institute (GB)
- Federal Medical Research Centre for Psychiatry and Narcology (RU)
Publication Details
- Journal
- Consortium Psychiatricum
- Published
- 2024-09-28
- DOI
- https://doi.org/10.17816/cp15488
- Citations
- 3
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Russian Foundation for Basic Research
- Russian Science Foundation
- Skolkovo Institute of Science and Technology
- Ministry of Health of the Russian Federation