Improved disease-specific survival in lentigo maligna treated with Mohs surgery over wide local excision: a retrospective cohort analysis

Lentigo maligna (LM), a subtype of melanoma in situ, typically occurs on sun-damaged skin of the head and neck in older men. Using the SEER database, the aim of this study was to compare disease-specific survival (DSS) outcomes between patients treated with wide local excision (WLE) and Mohs micrographic surgery (MMS), finding – on multivariable analysis – that MMS demonstrated improved 5- and 10-year DSS rates and a lower disease-specific mortality risk than WLE. Our findings highlight a potential DSS benefit of MMS for treating LM, although further research is required to confirm these findings and explore factors influencing treatment choices.