Wuwei Kushen Changrong capsule alleviates DSS-induced colitis in mice via inhibition of NLRP3 inflammasome and STAT3 pathway
The mechanisms through which CSCC protects against DSS-induced colitis may include upregulating Gpr43, inhibiting the STAT3/NLRP3 pathway, and suppressing inflammation factors like IL-17A. These findings highlight the mechanisms underlying CSCC's anti-colitis effects and suggest its potential as a therapeutic candidate for managing the progression of UC.
Authors
- Yang Feng
- Zhanqi Tong (ORCID: https://orcid.org/0000-0002-5986-7739)
- Jing Zhou (ORCID: https://orcid.org/0000-0002-4251-9068)
- Mingjun Chen (ORCID: https://orcid.org/0000-0003-0084-1312)
- Dan Luo (ORCID: https://orcid.org/0000-0002-0663-1706)
- Hengheng Dai
- Mingxiong Lin
- Chen Zhang (ORCID: https://orcid.org/0000-0003-0988-8723)
Institutions
- Chinese PLA General Hospital (CN)
- Longgang Central Hospital (CN)
- PLA Academy of Military Science (CN)
- Tianjin Beichen Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fphar.2024.1423012
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47