Amyloid precursor protein as a fibrosis marker in infants with biliary atresia
Biliary atresia patients with higher fibrosis scores according to Ishak have higher hepatic expression of amyloid-related genes while amyloid precursor protein accumulates in the liver and increases in the circulation. After a recent study revealed beta-amyloid deposition as a mechanism potentially involved in biliary atresia, we were able to correlate amyloid-metabolism-related transcript levels as well as amyloid precursor protein tissue and plasma levels with the degree of hepatic fibrosis. These findings suggest that amyloid precursor protein is a fibrosis marker in infants with biliary atresia, reinforcing the role of amyloid metabolism in the pathogenesis of this serious disease.
Authors
- Jan C. Kamp (ORCID: https://orcid.org/0000-0002-5002-409X)
- Lavinia Neubert (ORCID: https://orcid.org/0000-0003-4130-4185)
- Marie Uecker
- Mikal Obed
- Joachim Kübler
- Jan Stolk (ORCID: https://orcid.org/0000-0002-7887-386X)
- Sabina Janciauskiene (ORCID: https://orcid.org/0000-0001-7687-5258)
- Norman Junge (ORCID: https://orcid.org/0000-0002-3099-2667)
- Gertrud Vieten (ORCID: https://orcid.org/0000-0001-9341-4664)
- Tobias Welte (ORCID: https://orcid.org/0000-0002-9947-7356)
- Danny Jonigk (ORCID: https://orcid.org/0000-0002-5251-2281)
- Christopher Werlein (ORCID: https://orcid.org/0000-0002-7694-4257)
- Omid Madadi‐Sanjani (ORCID: https://orcid.org/0000-0002-7239-8973)
- Jannik Ruwisch (ORCID: https://orcid.org/0000-0003-1654-6668)
Institutions
- Leiden University Medical Center (NL)
- Medizinische Hochschule Hannover (DE)
- German Center for Lung Research (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1038/s41390-024-03582-w
- Citations
- 3
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.72