Hypervalent Iodine‐Mediated C3‐Trifluoropropionyloxylation of <i>N</i>‐Substituted Indoles
Abstract A metal‐free hypervalent iodine‐mediated C3‐trifluoropropionyloxylation of N ‐substituted indoles was developed. (Bis‐trifluoropropanoate)iodobenzene was used as both the oxidant and fluorine source. The reaction was sensitive to the N ‐protecting groups of the indoles. N ‐acylated indoles provided 3‐trifluoropropionyloxylated indoles, while 3‐trifluoropropionyloxylated oxindoles were generated from indoles bearing N ‐alkyl groups.
Authors
- Ming‐Xi Zhou
- Yao‐Fu Zeng (ORCID: https://orcid.org/0000-0003-2133-378X)
- Yue Wang (ORCID: https://orcid.org/0000-0002-4639-3714)
- Yu Guo (ORCID: https://orcid.org/0000-0001-5681-4503)
- Yuan Zhong (ORCID: https://orcid.org/0000-0003-1719-7623)
- Yao Tian
- Zi‐Pei Zeng
Institutions
- Hunan Vocational Institute of Technology (CN)
- University of South China (CN)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1002/slct.202403780
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.21
Funders
- University of South China