Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation
Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson's disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.
Authors
- Lvpiao Zheng (ORCID: https://orcid.org/0000-0003-0478-7034)
- Sana Amoozegar
- Jerrold L. Vitek (ORCID: https://orcid.org/0000-0002-2308-6535)
- Ziling Luo
- Luke A. Johnson (ORCID: https://orcid.org/0000-0002-9069-1436)
- Biswaranjan Mohanty (ORCID: https://orcid.org/0000-0002-3924-039X)
- Jing Wang (ORCID: https://orcid.org/0000-0002-9883-4972)
Institutions
- University of Minnesota (US)
- University of Minnesota, Waseca (US)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1038/s41531-024-00797-w
- Citations
- 2
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- University of Minnesota
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke