Neoadjuvant chemotherapy induces phenotypic mast cell changes in high grade serous ovarian cancer
Enhanced mast cell numbers, as well as activation and degranulation are a consequence of NACT exposure. Post-NACT mast cells displayed differing associations with survival outcomes that was dependent upon granule classification. Ultimately, mast cells represent a clinically relevant putative HGSOC immune target.
Authors
- Payton De La Cruz (ORCID: https://orcid.org/0000-0001-7483-4196)
- Julia McAdams
- Jasmine Ebott
- Chloe Kim (ORCID: https://orcid.org/0009-0000-1887-4003)
- Linda C. Hanley
- Nicole E. James (ORCID: https://orcid.org/0000-0003-4342-4770)
- Daniela Maiz
- Joyce Ou (ORCID: https://orcid.org/0000-0002-2930-4396)
- Corinne Jansen
Institutions
- Providence College (US)
- Brown University (US)
- Women & Infants Hospital of Rhode Island (US)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s13048-024-01516-y
- Citations
- 1
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Swim Across America
- National Institute of General Medical Sciences