Secreted protein TNA: a promising biomarker for understanding the adipose-bone axis and its impact on bone metabolism
We identified TNA as a secreted protein that inhibits osteoclast differentiation and bone resorption. While, it potentially promoted early osteoblast differentiation from bioinformatic results. TNA may play a role in bone metabolism through the adipose-bone axis.
Authors
- Dageng Huang (ORCID: https://orcid.org/0009-0002-3020-8139)
- Jiajia Ji (ORCID: https://orcid.org/0000-0003-0852-3335)
- Shaobo Wu (ORCID: https://orcid.org/0000-0001-6145-5314)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-3957-8312)
- Liangliang Wei
- Zhihao Xia (ORCID: https://orcid.org/0000-0001-5551-4082)
Institutions
- Xi'an Honghui Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s13018-024-05089-w
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00