Major recurrent aphthous ulcers treated with 5% amlexanox oral paste and rebamipide tablets- A case report with a brief literature review

Recurrent aphthous stomatitis (RAS) is the most prevalent ulcerative condition of the oral mucosa, frequently affecting otherwise healthy individuals. It appears as painful ulcers on the soft tissues of the mouth, especially on the buccal mucosa, labial mucosa, and tongue. RAS is categorized into minor, major, and herpetiform ulcers, depending on ulcer size, distribution, and the healing process. A detailed medical history and systemic evaluation can assist the physician in determining whether the condition is idiopathic or related to an underlying systemic ailment. disorder. The unclear etiology of aphthous ulcers has led to treatment approaches that are mostly empirical. Treatment options for oral aphthous ulcers encompass antibiotics, anti-inflammatory, immune modulators, anesthetics, and alternative remedies (such as herbal treatments). Managing RAS can be quite challenging, and there is currently no standardized or well-defined therapeutic regimen for it. While topical therapy is usually sufficient for most cases, systemic therapy may be used for patients with major RAS or those who suffer from numerous minor lesions. This paper deals with a case of major RAS in a 23-year-old male who was unresponsive to both topical and systemic steroid treatments. The patient showed notable improvement within a week of initiating therapy with 5% Amlexanox paste and rebamipide tablets, and no recurrences were observed during the 6-month follow-up