MicroRNA-124a promoted the differentiation of bone marrow mesenchymal stem cells into neurons through Notch signal pathway
This study investigated the possible mechanisms of microRNA-124a on the differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlying mechanism. β-Thiol ethanol induced Notch1 mRNA expression, microRNA-124a inhibitor reduced the effects of β-thiol ethanol on Notch1 mRNA expression in BMSCs. Baicalin induced Hes1 mRNA expression, and microRNA-124a inhibitor reduced the effects of baicalin on Hes1 mRNA expression in BMSCs. Si-Notch1 suppressed Hes1 mRNA expression in BMSCs. Baicalin increased the effects of Notch1 on Hes1 mRNA expression in BMSCs. Si-Notch1 increased cell growth of BMSCs. Baicalin reduced the effects of si-Notch1 on cell growth and the differentiation of BMSCs. We demonstrated that microRNA-124a promoted the differentiation of BMSCs into neurons through Notch/Hes1 signal pathway.
Authors
- Eryi Zhao (ORCID: https://orcid.org/0000-0002-0415-0482)
- Shixiong Huang (ORCID: https://orcid.org/0000-0001-5404-4664)
- Daimei Wang (ORCID: https://orcid.org/0000-0002-4171-9885)
- Shijun Hu (ORCID: https://orcid.org/0000-0002-0068-8429)
- Yanquan Chen
- Lijun Jing
- Hui Liang (ORCID: https://orcid.org/0000-0003-1341-6980)
- Ling Xie
- Zhongyan Zhao
Institutions
- Hainan General Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s40001-024-02061-6
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00