Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
Our results suggest that maternal circulating sEVs can act as novel mediators/modulators of mother-to-fetus stress communication. Further studies are needed to identify placental/fetal cellular targets of maternal sEVs and characterize their contribution to stress-induced sex-specific placental and fetal changes.
Authors
- Sebastián E. Illanes (ORCID: https://orcid.org/0000-0001-5433-9315)
- Alejandro Luarte (ORCID: https://orcid.org/0000-0001-9138-1854)
- Lorena Abarzúa-Catalán (ORCID: https://orcid.org/0000-0003-4684-0649)
- Maxs Méndez-Ruette (ORCID: https://orcid.org/0000-0001-7588-4531)
- Roberto J. Romero (ORCID: https://orcid.org/0000-0002-4448-5121)
- Mahesh Choolani (ORCID: https://orcid.org/0000-0001-8336-0973)
- Luis Federico Bátiz (ORCID: https://orcid.org/0000-0002-3043-8797)
- Úrsula Wyneken (ORCID: https://orcid.org/0000-0001-8913-4475)
- Lara J. Monteiro (ORCID: https://orcid.org/0000-0003-2078-380X)
- Mario Sánchez-Rubio
- Natalia Salazar
- Jacinta Sigala
- María Inés Godoy
- Ana del Valle
- Soledad Sandoval
Institutions
- Universidad de Santiago de Chile (CL)
- National University of Singapore (SG)
- Universidad de Los Andes, Chile (CL)
- University of Michigan (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Michigan State University (US)
Publication Details
- Journal
- Biological Research
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s40659-024-00548-4
- Citations
- 10
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- U.S. Department of Health and Human Services
- Australian Government
- Agencia Nacional de Investigación y Desarrollo
- National Institutes of Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Fondo de Fomento al Desarrollo Científico y Tecnológico
- NHLBI Division of Intramural Research