Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification
Gradual changes exist in metabolite abundances from the cecum to the rectum. The association between patient survival and distinct metabolites with anatomic subsite of the colorectum, reveals differences between cancers across the colorectum. These inter-subsite metabolic heterogeneities enrich the current understanding and substantiate previous studies that have challenged the conventional classification of right-sided, left-sided, and rectal cancers, by identifying specific metabolites that offer new biological insights into CRC subsite heterogeneity. The database designed in this study will enable researchers to delve into granular information on the CRC metabolome, which until now has not been available.
Authors
- Xavier Domingo-Almenara (ORCID: https://orcid.org/0000-0002-0133-6863)
- Domenica Berardi (ORCID: https://orcid.org/0000-0003-3244-6173)
- Caroline Helen Johnson (ORCID: https://orcid.org/0000-0002-5298-1299)
- Montana T. Morris (ORCID: https://orcid.org/0000-0002-1794-1590)
- Daniel Kerekes (ORCID: https://orcid.org/0000-0001-9467-1486)
- Nicholas J. W. Rattray (ORCID: https://orcid.org/0000-0002-3528-6905)
- Sajid Khan (ORCID: https://orcid.org/0000-0001-9897-6025)
- Philip B. Paty (ORCID: https://orcid.org/0000-0002-7045-2112)
- Abhishek Jain (ORCID: https://orcid.org/0000-0001-5252-4832)
- Trisha Arora
- Lingeng Lu
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of Strathclyde (GB)
- Yale Cancer Center (US)
- Yale University (US)
- Technological Center of Nutrition and Health (ES)
- Yale New Haven Health System (US)
- Centre for Omic Sciences (ES)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s12943-024-02133-5
- Citations
- 14
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 3.96
Funders
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- Medical Research Council