Morphological Changes in Pyramidal Neurons of Frontal Cortex of the Rat`s Brain During Experimental Myocardial Ischemia

Objective: To analyze changes in morphological characteristics of rat frontal cortex neurons during myocardial ischemia. Methodology: Experiments were performed on 12 male non-pedigreed white rats with an initial weight of 240±20 g. Myocardial ischemia in white mongrel rats was modeled by isoprenaline administration. The material was sampled 24 hours after the last injection of the drug. Results: Experimental myocardial ischemia was accompanied by a slight decrease in neuronal size and pericarion deformation. The number of hyperchromic wrinkled neurons increased. Wrinkled neurons constituted the majority of cells in the studied cortex section. Conclusion: During experimental myocardial ischemia, parietal cortex neurons decreased in size by 3.3% compared to control (p<0.05), the shape of neurons slightly changed - they became more elongated (by 6.4%) (p<0.05), while the form factor decreased by 5.5% (p<0.05) compared to control. The number of normochromic neurons decreased by 8% (p<0.05), while the number of hyperchromic neurons increased 2-fold compared to controls. Hyperchromic shriveled neurons appeared, their number amounted to 4.5% of the number of all neurons.