Photoplethysmography‐Based Angiography of Skin Tumors in Arbitrary Areas of Human Body
Noninvasive, rapid, and robust diagnostic techniques for clinical screening of tumors located in arbitrary areas of the human body are in demand. To address this challenge, we analyzed the feasibility of photoplethysmography-based angiography for assessing vascular structures within malignant and benign tumors. The proposed hardware and software were approved in a clinical study involving 30 patients with tumors located in the legs, torso, arms, and head. High-contrast and detailed vessel maps within both benign and malignant tumors were obtained. We demonstrated that capillary maps are consistent and can be interpreted using well-established dermoscopic criteria for vascular morphology. Vessel mapping provides valuable details, which may not be available in dermoscopic images and can aid in determining whether a tumor is benign or malignant. We believe that the proposed approach may become a valuable tool in the preliminary cancer diagnosis and is suitable for large-scale screening.
Authors
- Gaiane A. Gabrielian (ORCID: https://orcid.org/0000-0002-9238-4165)
- Alexander Machikhin (ORCID: https://orcid.org/0000-0002-2864-3214)
- Ekaterina V. Orlova (ORCID: https://orcid.org/0000-0002-1684-8781)
- Ekaterina Rudenko
- Olga Yu. Olisova (ORCID: https://orcid.org/0000-0003-2482-1754)
- Anastasia Guryleva (ORCID: https://orcid.org/0000-0003-2239-3725)
- Marina Sekacheva (ORCID: https://orcid.org/0000-0003-0015-7094)
- Olga Lobanova (ORCID: https://orcid.org/0000-0002-6813-3374)
- V. A. Smolyannikova (ORCID: https://orcid.org/0000-0002-7759-5378)
- Т. А. Демура (ORCID: https://orcid.org/0000-0002-6946-6146)
- Evgeniya Kulikova (ORCID: https://orcid.org/0009-0005-0595-4422)
- Ludmila Smirnova
- Michail Volkov
Institutions
- Sechenov University (RU)
- Federal State Budgetary Institution of Science "Scientific and Technological Center of Unique Instrumentation" of the Russian Academy of Sciences (RU)
Publication Details
- Journal
- Journal of Biophotonics
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1002/jbio.202400242
- Citations
- 4
- Primary Topic
- Optical Coherence Tomography Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Ministry of Science and Higher Education of the Russian Federation
- Russian Academy of Sciences