Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes
HuNSG-QUAD mice are competent for the NF-κB, interferon and inflammasome effectors of human innate immunity, and can thus be utilized to investigate signaling mechanisms and pharmacological targeting of human inflammatory responses in an <i>in vivo</i> setting.
Authors
- Elisabeth De Leeuw (ORCID: https://orcid.org/0000-0002-7826-8141)
- Geert Loo (ORCID: https://orcid.org/0000-0002-8427-4775)
- Andy Wullaert (ORCID: https://orcid.org/0000-0001-5012-654X)
- Linos Vandekerckhove (ORCID: https://orcid.org/0000-0002-8600-1631)
- Bart N. Lambrecht (ORCID: https://orcid.org/0000-0003-4376-6834)
- Hannah Stocks
Institutions
- University of Antwerp (BE)
- Ghent University Hospital (BE)
- Ghent University (BE)
- VIB-UGent Center for Inflammation Research (BE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fimmu.2024.1419117
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Fonds Wetenschappelijk Onderzoek
- Universiteit Gent
- Vlaamse regering