The characteristics of intestinal microbiota in patients with type 2 diabetes and the correlation with the percentage of T-helper cells
This study provided a preliminary picture of the crosstalk between the intestinal microbiome and systematic Th cells in patients with T2D. The findings of the study suggested that the network relationship among the intestinal microbiota, metabolites, and CD4+T lymphocyte immunity was unbalanced in the patients with T2D, which might have promoted the development of T2D. This presents a therapeutic opportunity to modulate gut immune reaction and then chronic inflammation by manipulating microbiome-specific Th-cell response.
Authors
- Shuyuan Chu (ORCID: https://orcid.org/0000-0002-1543-0877)
- Jinyan Li (ORCID: https://orcid.org/0000-0003-1833-7413)
- Qingfeng Shi (ORCID: https://orcid.org/0000-0002-3388-7272)
- Fan Yang (ORCID: https://orcid.org/0000-0003-0165-9803)
- Longqin Wei
- Siyan Lu
- Shenghua Qin
Institutions
- Guilin Medical University (CN)
- Guilin University of Aerospace Technology (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- 181st Hospital of Chinese People's Liberation Army (CN)
- Affiliated Hospital of Guilin Medical College (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fmicb.2024.1443743
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China