Lipocalin-2 drives neuropsychiatric and cutaneous disease in MRL/lpr mice
As there was no effect on systemic disease, our results suggest that the inflammatory effects of LCN2 were localized to the skin and brain in this model. This study further establishes LCN2 as a potential target to ameliorate organ injury in SLE, including neuropsychiatric and cutaneous disease.
Authors
- Sayra J. Garcia
- Carla M. Cuda (ORCID: https://orcid.org/0000-0002-2022-8171)
- Jinghang Zhang (ORCID: https://orcid.org/0000-0003-1436-6460)
- Elise V. Mike (ORCID: https://orcid.org/0000-0002-5913-4332)
- Chaim Putterman (ORCID: https://orcid.org/0000-0002-3204-6068)
Institutions
- Northwestern University (US)
- Albert Einstein College of Medicine (US)
- Bar-Ilan University (IL)
- Johns Hopkins University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fimmu.2024.1466868
- Citations
- 5
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.09