Gut microbiota and interstitial cystitis: exploring the gut-bladder axis through mendelian randomization, biological annotation and bulk RNA sequencing
Our two-sample Mendelian randomization study established a causal relationship between gut microbiota and interstitial cystitis. Furthermore, our identification of a host gene-microbiota association offers a new avenue for investigating the potential pathogenesis of interstitial cystitis and suggests avenues for the development of personalized treatment strategies.
Authors
- Xiang Zhou (ORCID: https://orcid.org/0000-0003-0278-6636)
- Chaowei Fu (ORCID: https://orcid.org/0000-0003-0966-8552)
- Fengping Liu
- Ninghan Feng (ORCID: https://orcid.org/0000-0002-0892-6102)
- Shengkai Jin (ORCID: https://orcid.org/0000-0003-4641-6928)
- Yuhua Zhou (ORCID: https://orcid.org/0009-0005-4490-804X)
- Yu Zhao (ORCID: https://orcid.org/0000-0003-0831-3784)
- Jing Lv (ORCID: https://orcid.org/0000-0002-5751-7786)
Institutions
- Jiangnan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fimmu.2024.1395580
- Citations
- 10
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 5.35
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China