Accelerated calciprotein crystallization time (T50) is correlated with impaired lung diffusion capacity in systemic sclerosis
This study provides indications for a disturbed mineral buffering system in SSc. Increased serum calcification propensity (lower T50) is correlated with impaired lung diffusion capacity, suggesting a possible role of deranged mineral buffering in disease progression. Further studies are required to confirm these observations in larger cohorts and to investigate a putative functional relevance.
Authors
- Helmut Lackner (ORCID: https://orcid.org/0000-0002-0159-3720)
- Ioana Alesutan (ORCID: https://orcid.org/0000-0002-2145-3653)
- Andreas Pasch (ORCID: https://orcid.org/0000-0002-7439-0748)
- Norbert Sepp
- Mehdi Razazian (ORCID: https://orcid.org/0000-0001-8806-6773)
- Jakob Voelkl (ORCID: https://orcid.org/0000-0002-6318-5087)
- Thomas Pütz (ORCID: https://orcid.org/0000-0003-2101-448X)
- Marija Geroldinger‐Simić (ORCID: https://orcid.org/0000-0003-2789-1862)
- Beatrice Krennmayr
- Victoria Pernsteiner
- Azmat Sohail
Institutions
- Johannes Kepler University of Linz (AT)
- Medical University of Graz (AT)
- Humboldt-Universität zu Berlin (DE)
- German Centre for Cardiovascular Research (DE)
- Krankenhaus der Elisabethinen (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fimmu.2024.1425885
- Citations
- 3
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- Austrian Science Fund
- Deutsche Stiftung Sklerodermie