Parallel evolution of fluconazole resistance and tolerance in Candida glabrata
This study highlights that while tolerance to fluconazole is a common response in <i>Candida</i> species, the specific molecular mechanisms and evolutionary pathways that lead to this response vary between species. Our findings emphasize the importance of understanding the regulation of fluconazole tolerance in different <i>Candida</i> species to develop effective therapeutic strategies.
Authors
- Liangsheng Guo (ORCID: https://orcid.org/0000-0002-1596-0851)
- Yi Xu (ORCID: https://orcid.org/0000-0001-8971-9334)
- Yubo Dong (ORCID: https://orcid.org/0009-0003-3272-1363)
- Chen Wang (ORCID: https://orcid.org/0000-0002-2727-7240)
- Lijun Zheng (ORCID: https://orcid.org/0000-0002-3283-3619)
Institutions
- Soochow University (CN)
- 82th Hospital of Pla (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fcimb.2024.1456907
- Citations
- 8
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 3.11