Inflammatory spindle cell PEComa of the lung with <i>YAP1::TFE3</i> fusion: a report of two cases and a potential relationship with clear cell stromal tumour
We present two cases of inflammatory spindle to epithelioid cell tumours of the lungs with myomelanocytic differentiation and YAP1::TFE3 fusion. This unique morphology and gene fusion suggest that these tumours may constitute a distinct subset of lung PEComa. Furthermore, morphological and molecular overlap with CCST-L gives rise to a hypothesis of a potential inherent relationship between PEComa and CCST-L.
Authors
- Shogo Nishino
- Taisuke Mori (ORCID: https://orcid.org/0000-0003-1838-7883)
- Akihiko Yoshida (ORCID: https://orcid.org/0000-0002-3373-0099)
- Shun‐ichi Watanabe (ORCID: https://orcid.org/0000-0003-4456-3932)
- Naoki Kojima (ORCID: https://orcid.org/0000-0001-6963-3824)
- Tetsuro Taki (ORCID: https://orcid.org/0000-0001-8654-6896)
- Yasushi Yatabe (ORCID: https://orcid.org/0000-0003-1788-559X)
- Yukiko Sasahara (ORCID: https://orcid.org/0009-0000-2691-9566)
- Tomohiro Miyoshi (ORCID: https://orcid.org/0000-0002-6311-0691)
- Hiroki Imada (ORCID: https://orcid.org/0000-0002-3945-9586)
- Genichiro Ishii
Institutions
- Juntendo University (JP)
- Chiba Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- Tokyo National Hospital (JP)
- Social Insurance Saitama Chuo Hospital (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Histopathology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1111/his.15328
- Citations
- 8
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- National Cancer Center Japan
- Japan Society for the Promotion of Science