Palladium‐Catalyzed Synthesis of Pyrrolo[1,2‐α]Pyrazines From N‐Phenacyl Pyrrole‐2‐Carbonitriles and Aryl Boronic Acids
ABSTRACT Herein, we have developed palladium‐trifluoroacetate‐catalyzed carbo‐palladation reaction of pyrrole‐2‐carbonitriles and aryl boronic acids leading to functionally diverse pyrrolo[1,2‐α]pyrazines under thoroughly optimized reaction conditions. The reaction proceeded smoothly and allowed the diversity‐oriented synthesis of pyrrolo[1,2‐α]pyrazines with broad substrate scope with respect to pyrrole‐2‐carbonitriles and aryl boronic acids.
Authors
- Hayoung Jeon (ORCID: https://orcid.org/0000-0001-8540-0019)
- Seunghwan Shim (ORCID: https://orcid.org/0000-0003-1121-1746)
- Kyeong Lee (ORCID: https://orcid.org/0000-0002-5455-9956)
- Hitesh B. Jalani (ORCID: https://orcid.org/0000-0002-2442-9798)
- Hyejun Park (ORCID: https://orcid.org/0000-0001-6658-9610)
- Hwa‐Young Lee (ORCID: https://orcid.org/0000-0003-2591-1436)
- Yongseok Choi (ORCID: https://orcid.org/0000-0002-3622-3439)
- Kiho Lee (ORCID: https://orcid.org/0000-0001-6151-6543)
- Jae Kyun Lee
Institutions
- Korea University (KR)
- Dongguk University (KR)
- Sejong University (KR)
- Korea Institute of Science and Technology (KR)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1002/jhet.4898
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and ICT, South Korea