Association of <i>HMGCR</i> rs17671591 and rs3761740 with lipidemia and statin response in Uyghurs and Han Chinese
We found that <i>HMGCR</i> rs3761740 was correlated with the levels of TC, LDL-C, and non-HDL-C before and after oral statin in Uyghurs, but not with blood lipid levels in the Han population. In the Uyghur population, <i>HMGCR</i> rs17671591 was associated with the level of LDL-C before and after oral statin, and also affected the changes of LDL-C after oral statin.
Authors
- Sen Liu (ORCID: https://orcid.org/0009-0007-7570-5514)
- Zhen-Yan Fu (ORCID: https://orcid.org/0000-0003-2194-1275)
- Menglong Jin
- Mengwei Wei
- Huayin Li
- Subinuer Jureti
- Shuai Liu (ORCID: https://orcid.org/0000-0002-0699-2296)
- Ziyang Liu (ORCID: https://orcid.org/0000-0002-4828-3519)
- Sifu Luo
- Kai Yang
- Yang Zhou (ORCID: https://orcid.org/0000-0002-2945-882X)
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2024-09-27
- DOI
- https://doi.org/10.7717/peerj.18144
- Citations
- 2
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China