Synthesis of New Tetracyclic Ring Systems: Bridged Derivatives of Hydroxy‐, Sulfanyl‐ and Amino‐Substituted Dibenzo[c,<i>f</i>][1,2]Thiazepine <i>S</i>,<i>S</i>‐Dioxides
Abstract In continuation of our commitment to the synthesis of new ring systems based on the 6,11‐dihydrodibenzo[ c , f ][1,2]thiazepine 5,5‐dioxide core of the antidepressant drug tianeptine, we have incorporated two‐ and/or three‐carbon bridges between the nitrogen atom of the sulfonamide moiety and the N ‐, O ‐ or S ‐substituent at position 11 of the tricycle. The synthesis of 5 new ring systems is described and demonstrated with several target compounds.
Authors
- Lóránd Kiss (ORCID: https://orcid.org/0000-0003-2346-9816)
- András Dancsó (ORCID: https://orcid.org/0000-0001-8460-217X)
- Balázs Volk (ORCID: https://orcid.org/0000-0002-2019-1874)
- Mária Tóthné Lauritz
- Gyula Simig (ORCID: https://orcid.org/0000-0002-2569-6476)
- Gábor Berecz
- Dávid Szabó
Institutions
- Egis Pharmaceuticals (Hungary) (HU)
- HUN-REN Research Centre for Natural Sciences (HU)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1002/ejoc.202400835
- Citations
- 2
- Primary Topic
- Phenothiazines and Benzothiazines Synthesis and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap