Hybrid Deposition Modeling Technology for Preparing Rocket‐Separation 3D‐Print Combination Tablet with Greater Compliance for the Treatment of <i>Helicobacter Pylori</i> Infection

Abstract Currently, standard quadruple therapy is the primary treatment for Helicobacter pylori infection; however, compliance is low due to its complicated dose regimen. 3D‐printed combination tablets offer a promising strategy to simplify dose regimens due to their flexible structure. However, it is difficult to print combination tablets with a single printing technique because of the different physicochemical properties of the drugs. In this study, a hybrid deposition modeling (HDM) 3D printer is developed for the first time, concentrating the advantages of fused deposition modeling technology and semi‐solid extrusion technology, to prepare “rocket‐separated” combination tablets containing four drugs with different release behaviors. In 0.1 m HCl medium (mimicking gastric environment), the interlayer of the tablet containing bismuth potassium citrate erodes within 5 min, then the top and bottom layers separate, with the top one floating up to the surface of the medium, starting to release metronidazole and doxycycline after 1.5 h, the omeprazole enteric bottom layer releases in PBS 6.8 medium (mimicking intestinal environment) within 2 h. Overall, this combination tablet is suitable for actual clinical needs and avoids the chance of missed or wrong dosing. Moreover, HDM technology opens the door for future integration of multiple technologies in 3D printing formulations.