Maternele en obstetrische uitkomsten in vrouwen met mucovisidose: een retrospectieve case series van patiënten uit UZ Leuven

Maternal and obstetric outcomes in women with cystic fibrosis: a retrospective case series of patients in UZ Leuven Introduction: Cystic fibrosis (CF) is a genetic disease, caused by a mutation in the CFTR gene. This mutation may lead to pulmonary and endocrine complications. With CF therapies improving, the life expectancy of CF patients has increased and so has the number of pregnancies. Methodology: The case series describes the maternal and obstetric outcomes for 8 patients who had their pregnancy follow-up and delivery at the University Hospital of Leuven between January 2015 and December 2021. Based on a review of the literature, a multidisciplinary approach to handle pregnancy in CF patientson multiple levels (fertility, obstetric, pneumology, endocrine) is worked out. Results: In our patient group all patients were referred for genetic counseling and 50% of the patients underwent fertility treatment. For the obstetric results, 2 out of 8 patients had a preterm delivery, there were no infants with low birth weight (LBW) or intra-uterine growth restriction (IUGR) seen. 6 out of 8 patients delivered vaginally from which 2 had an assisted delivery. For the pneumological state, all patients were screened prenatally and had a prenatal FEV1 >60%. During pregnancy, 4 out of 8 patients required hospitalization for IV antibiotics for a CF exacerbation. 2 out of 8 patients had the diagnosis of CF-related diabetes (CFRD). Discussion: With appropriate patient selection (based on preconceptual nutritional status, pulmonary and cardiac function, bacterial burden and pancreatic function) and a multidisciplinary approach during pregnancy, good obstetric and maternal outcomes can be expected.