Visualizing Immune Checkpoint Inhibitors Derived Inflammation in Atherosclerosis
Accelerated atherosclerotic plaque inflammation triggered by anti-PD1 treatment can be noninvasively detected by <sup>64</sup>Cu-DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-ECL1i (extracellular loop 1 inverso) PET. Aggravated plaque inflammation is time- and dose-dependent and predominately mediated by IFNγ signaling. This study warrants further investigation of CCR2 PET as a noninvasive approach to visualize atherosclerotic plaque inflammation and explore the underlying mechanism following ICI treatment.
Authors
- Junedh Amrute (ORCID: https://orcid.org/0000-0002-6851-0168)
- Kory J. Lavine (ORCID: https://orcid.org/0000-0003-1948-9945)
- Hannah Luehmann (ORCID: https://orcid.org/0000-0002-7516-6772)
- Alexandria Li
- Deborah Sultan
- Andrea Bredemeyer (ORCID: https://orcid.org/0000-0003-2970-5998)
- Xiuli Zhang
- Lisa Detering (ORCID: https://orcid.org/0000-0001-7061-1024)
- Pan Ma (ORCID: https://orcid.org/0000-0002-0815-849X)
- Gyu Seong Heo (ORCID: https://orcid.org/0000-0001-6200-4742)
- Divangana Lahad
- Yongjian Liu (ORCID: https://orcid.org/0000-0002-1118-1535)
- Lan‐Lan Lou (ORCID: https://orcid.org/0000-0002-2569-3718)
Institutions
- Washington University in St. Louis (US)
- Mallinckrodt (United States) (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1161/circresaha.124.324260
- Citations
- 18
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- Fondation Leducq
- National Institutes of Health