Exploring the Potential Effects and Mechanism of Astragalus Membranaceus in Treating Ischemic Heart Failure Based on Network Pharmacology and Experimental Verification
Through integrated network pharmacological analysis, molecular docking technology, and in vitro experimental validation, it was demonstrated that AM can effectively mitigate IHF through activating PI3K-AKT signaling pathway. These findings significantly advance our understanding of the molecular mechanisms in IHF treatment and contribute further to promoting the clinical application of AM.
Authors
- Chaoqun Xing
- Xiao‐Liang Xing (ORCID: https://orcid.org/0000-0003-3075-3102)
- Xuemei Zhang (ORCID: https://orcid.org/0000-0002-8402-3888)
- Zhiyong Yao (ORCID: https://orcid.org/0000-0003-4663-2516)
- Hai Luo
- Minjiang Huang
Institutions
- Hunan University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2024-09-27
- DOI
- https://doi.org/10.2174/0113862073322602240909113946
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00