Wnt/B-catenin Activation and TP53 Mutations Associate With Distinct Immune Profiles in Advanced Thyroid Cancer
Our study indicates a potential correlation between the activation of the Wnt/β-catenin pathway and the development of cold thyroid cancers, which may be mediated by the suppression of CCL4 expression. Concurrently, mutations in the p53 gene appear to be linked with the occurrence of hot thyroid cancers. While these associations are compelling, they are based on observational data. Experimental research is necessary to determine the causal relationships underlying these findings.
Authors
- Vittorio Bini (ORCID: https://orcid.org/0000-0001-8404-2918)
- Efisio Puxeddu (ORCID: https://orcid.org/0000-0001-9611-6216)
- Clara Ugolini (ORCID: https://orcid.org/0000-0002-3489-8280)
- Elisa Menicali
- Riccardo Giannini (ORCID: https://orcid.org/0000-0001-9740-0219)
- Sonia Moretti (ORCID: https://orcid.org/0009-0009-2250-1803)
- Angelo Sidoni (ORCID: https://orcid.org/0000-0002-8458-5901)
- Martina Mandarano (ORCID: https://orcid.org/0000-0001-5019-4825)
- Renato Colella
- Fulvio Basolo (ORCID: https://orcid.org/0000-0003-1657-5020)
- Martina Guzzetti
- Silvia Morelli
- Edoardo Talpacci
Institutions
- University of Pisa (IT)
- University of Perugia (IT)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1210/clinem/dgae667
- Citations
- 4
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.43