mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis
Our data suggest that mTOR activation caused by TSC2 deletion increases PRAS40 expression through miR-142-3p repression. PRAS40 depletion or the pharmacological induction of miR-142-3p expression impaired TSC2 deficiency-associated renal cystogenesis. Therefore, harnessing mTOR/miR-142-3p/PRAS40 signaling cascade may mitigate hyperactivated mTOR-related diseases.
Authors
- Sajid Jalal (ORCID: https://orcid.org/0000-0001-6321-4899)
- Chuanxin Zhai
- Zhaolai Qi
- Hongming Teng
- Shuyun Zhao (ORCID: https://orcid.org/0000-0001-7061-2318)
- Lin Huang (ORCID: https://orcid.org/0000-0001-8254-7664)
- Tianhua Zhang (ORCID: https://orcid.org/0000-0002-6180-0381)
- Yue Wang (ORCID: https://orcid.org/0000-0001-6936-5081)
- Ting Zhang (ORCID: https://orcid.org/0000-0001-8074-8999)
- Hongbing Zhang (ORCID: https://orcid.org/0000-0001-6291-1027)
- Yufei Bo
- Yin Lu (ORCID: https://orcid.org/0000-0003-0633-7715)
- Jiasheng Zhou (ORCID: https://orcid.org/0009-0009-5310-3920)
- Shuai Hao (ORCID: https://orcid.org/0009-0005-9478-9210)
- Dongyan Gao
- Xinran Chen (ORCID: https://orcid.org/0009-0007-0879-1360)
Institutions
- Dalian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s11658-024-00638-x
- Citations
- 1
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- National Natural Science Foundation of China