A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ
CircSPECC1 was downregulated in recurrent GBM compared with primary GBM. The m6A reader protein IGF2BP1 could promote the expression and stability of circSPECC1. The sequence of SPECC1-415aa, which is encoded by circSPECC1, can inhibit the binding of ANXA2 to EGFR by competitively binding to ANXA2 and inhibiting the phosphorylation of EGFR and AKT, thereby restoring the sensitivity of TMZ-resistant GBM cells to TMZ.
Authors
- Runze Yu (ORCID: https://orcid.org/0000-0001-9889-0299)
- Dazhao Peng
- Ze‐Sheng Li (ORCID: https://orcid.org/0000-0002-6993-8414)
- Jinquan Cai (ORCID: https://orcid.org/0000-0002-9502-769X)
- Zhenyu Zhang (ORCID: https://orcid.org/0000-0002-2309-3145)
- Bo Wang (ORCID: https://orcid.org/0000-0001-7934-3580)
- Shu Zhang (ORCID: https://orcid.org/0000-0002-4380-1268)
- Lei Han (ORCID: https://orcid.org/0000-0002-0707-5027)
- Cheng Wei
- Boyuan Jing
- Jianning Zhang
Institutions
- Harbin Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s11658-024-00644-z
- Citations
- 11
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- National Natural Science Foundation of China