Characterization of Anticancer Drug Protomers Using Electrospray Ionization and Ion Mobility Spectrometry–Mass Spectrometry
We used electrospray ionization and ion mobility spectrometry-mass spectrometry to detect and characterize the three anticancer drugs palbociclib, copanlisib, and olaparib. Ion mobility-mass spectrometry and density functional theory revealed that these compounds generate isomers during ionization (protomers) due to the presence of multiple protonation sites within their chemical structures. Our work has implications for understanding the solution- and gas-phase chemistry of these molecules during spray-based ionization processes.
Authors
- Pascal Schorr (ORCID: https://orcid.org/0000-0001-7067-7883)
- Dietrich A. Volmer (ORCID: https://orcid.org/0000-0003-2820-1480)
- Kevin Pagel (ORCID: https://orcid.org/0000-0001-8054-4718)
- Jerome Riedel (ORCID: https://orcid.org/0000-0003-1361-715X)
- Borislav Kovačević (ORCID: https://orcid.org/0000-0002-8000-4508)
- Pallab Basuri (ORCID: https://orcid.org/0000-0002-8627-6555)
- Marc Safferthal (ORCID: https://orcid.org/0009-0006-9267-3940)
Institutions
- Humboldt-Universität zu Berlin (DE)
- Ruđer Bošković Institute (HR)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Journal of the American Society for Mass Spectrometry
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1021/jasms.4c00233
- Citations
- 5
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Max-Planck-Gesellschaft