Links between mutations in functionally separate arms of mitochondrial complex I and responses to volatile anesthetics
Mutations in different arms of Complex I resulted in different behavioral sensitivities and toxicities to isoflurane and sevoflurane, indicating that (i) the anesthetics have mechanisms of action that involve arms of Complex I to different extents and (ii) the lack of behavioral hypersensitivity does not preclude susceptibility to anesthetic toxicity.
Authors
- Luke A. Borchardt (ORCID: https://orcid.org/0000-0002-1237-251X)
- David A. Wassarman (ORCID: https://orcid.org/0000-0002-7042-9561)
- Zachariah P. G. Olufs (ORCID: https://orcid.org/0000-0002-7812-8261)
- Amanda R. Scharenbrock
- Misha Perouansky (ORCID: https://orcid.org/0000-0003-1759-5277)
Institutions
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- Pediatric Anesthesia
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1111/pan.14999
- Citations
- 1
- Primary Topic
- Physiological and biochemical adaptations
- Type
- article
- Field-Weighted Citation Impact
- 0.46