Dynamic changes in the real-time glomerular filtration rate and kidney injury markers in different acute kidney injury models
In this study, we dynamically monitored the glomerular filtration rate and other assessment of renal function and markers of injury in various mice models of acute kidney injury. Male C57BL/6 mice were utilized to establish acute kidney injury models of sepsis, ischemia reperfusion, cisplatin, folic acid, aristolochic acid and antibiotic. In addition to the real time glomerular filtration rate, renal LCN-2 and HAVCR-1 mRNA expression levels, and serum creatinine, urea nitrogen and cystatin c levels were also used to evaluate renal function. In addition, the protein levels of LCN-2 and HAVCR-1 in renal, serum and urine were measured. Our results demonstrated that the changes in biomarkers always lagged the real time glomerular filtration rate during the progression and recovery of renal injury. Cystatin-c can reflect renal injury earlier than other markers, but it remains higher in the recovery stage. Perhaps the glomerular filtration rate does not reflect the greater injury caused by vancomycin plus piperacillin.
Authors
- Yahui Peng
- Yang Zhou (ORCID: https://orcid.org/0000-0002-9087-0522)
- Xibo Wang (ORCID: https://orcid.org/0000-0002-4220-9246)
- Linqiong Liu
- Pengfei Huang (ORCID: https://orcid.org/0000-0002-3012-3867)
- Mengyao Yuan (ORCID: https://orcid.org/0000-0002-7339-689X)
- Kaijiang Yu (ORCID: https://orcid.org/0000-0001-8456-9664)
- Changsong Wang (ORCID: https://orcid.org/0000-0002-0079-5259)
- Lifeng Shen
- Yuhan Liu (ORCID: https://orcid.org/0000-0003-1990-4184)
- Xinran Wang (ORCID: https://orcid.org/0000-0002-5846-4743)
- Yanqi Liu (ORCID: https://orcid.org/0000-0003-3499-0201)
- Hongxu Li (ORCID: https://orcid.org/0000-0001-7578-416X)
- Yu Xiao
- Yuchen Song
- Yu Xin
- Yuxin Zhou
- Yuxi Liu (ORCID: https://orcid.org/0000-0002-6105-8594)
- Dawei Wang (ORCID: https://orcid.org/0009-0005-8466-3497)
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang Provincial Hospital (CN)
- Education Department of Heilongjiang Province (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12967-024-05667-w
- Citations
- 14
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 4.75
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province